Daily Mail - The Cancer Grenade 31 October 2015

The cancer grenade: How tiny bubbles carrying drugs in the blood can blast tumours 

  • Scientists have created 'drug grenades' armed with heat sensitive triggers
  • Microscopic bubbles loaded with drugs are injected into the drug stream 
  • When they reach the tumour the bubbles explode targeting the tumour 
  • Treatment could reduce debilitating side effects caused by chemotherapy 

By Ben Spencer Medical Correspondent For The Daily Mail

Published: 00:06, 31 October 2015 | Updated: 00:23, 31 October 2015

 

 

Scientists have developed drug ‘grenades’ armed with heat sensitive triggers which promise to revolutionise the war on cancer.

The breakthrough means the debilitating side effects of chemotherapy could be reduced and cheap medication made more effective.

Experts at Manchester University have developed tiny ‘grenades’ – microscopic bubbles which are loaded with lifesaving drugs and then injected into the bloodstream. When the bubbles – called liposomes – reach a tumour they explode, delivering chemotherapy drugs exactly where they are needed.

 

 

The technology has the potential to transform the lives of countless patients. Sending medication directly to a tumour would make it far more effective.

And because the entire blood stream is not being flooded with the drug, the usual gruelling side effects of chemotherapy would be vastly reduced. 

 

 

There would be less nausea and hair loss, and a lower risk of infection.

Scientists have for years been trying to come up with better ways to deliver chemotherapy.

A GLASS OF COKE HELPS CANCER

A glass of Coke could be an unlikely new weapon against cancer. 

Tests have shown it boosts the amount of medicine absorbed into the blood when patients swallow cancer pills.

Researchers at Erasmus Medical Centre in the Netherlands discovered the drink’s benefits when they tested it on patients taking lung tumour pill Tarceva. 

They believe the same effects are likely to be seen in a dozen other drugs for breast cancer, kidney cancer and leukaemia.

A 250ml glass of regular Coca-Cola increased drug absorption by an average of 40 per cent. Other cola brands are likely to work just as well.

Teams around the world are working on ‘nanotechnology’ methods such as this to carry drugs safely through the body.

But while several have come up with microscopic capsules to carry drugs through the blood stream, few have worked out how to get them to release the medication in exactly the right place.

The Manchester team solved this problem by developing tiny heat-sensitive capsules made of cell membrane. The bubbles are stable at a normal 37C blood temperature but when temperatures rise by 5C they burst, releasing the drugs.

To achieve this the tumour is heated to 42C, either by a hot pad or warm water bath if the cancer is near the surface, or via a long hot needle if it is deep in the body.

The Manchester academics, who will present their results at the National Cancer Research Institute Cancer Conference, which starts today in Liverpool, have shown their technology works in mice. 

Several other teams are carrying out nanotechnology clinical trials on humans, using slightly different delivery techniques.

But Manchester University’s Professor Kostas Kostarelos said these methods are flawed as the liposomes burst too early, releasing the drugs in the wrong place.

 

His team are convinced their heat-sensitive liposomes hold huge potential as they hold the drugs safely until they reach just the right temperature. 

Professor Kostarelos added: ‘Once they reach a “hotspot” of warmed-up cancer cells, the pin is effectively pulled and the drugs are released.’

If the Manchester team are successful, and the work is still at an early stage, doctors could make better use of cheap existing drugs by more effectively delivering them to the right part of the body.


 

Read more: http://www.dailymail.co.uk/health/article-3297582/The-cancer-grenade-tiny-bubbles-carrying-drugs-blood-blast-tumours.html#ixzz3tMOgfsIR
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